Robert Clark, M.D.
University of Connecticut Health Center
Department of Immunology
263 Farmington Avenue
Farmington, CT 06030-1310
Dr. Clark’s laboratory is interested in the cell biology of the T lymphocyte as at relates to autoimmune diseases. The immune response in autoimmune diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as animal models for these diseases are studied at the level of the T cell. T cell gene usage, T cell function and activation, and T cell migration and homing are studied using T cell cloning and molecular biological approaches. The understanding of basic T cell function as it relates to autoimmune mediated pathology is the overall goal of this laboratory.
Wohlfert, EA, Gorelik, L, Mittler, R, Flavell, RA, Clark, RB.Cutting Edge Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T cell TGF-β Sensitivity in Vitro and in Vivo. J. Immunol. 176: 1316-1320, 2006.
Wohlfert, EA, Nichols, FC, Nevius, E, Clark, RB. PPARγ and Immunoregulation: Enhancement of Regulatory T cells Through PPARγ-Dependent and Independent Mechanisms. J. Immunol. 2007 Apr 1;178: 4129-35.
Wohlfert EA and Clark, RB. Vive la Résistance!– the PI3K–Akt pathway can determine target sensitivity to regulatory T cell suppression. Trends in Immunology. 2007 Apr;28(4):154-60.
Wohlfert E, Callahan M, Clark RB: Resistance to CD4+CD25+ Regulatory T Cells and TGF-b in Cbl-b-/- Mice. J. Immunol. 173: 1059-1065, 2004.
Clark RB. The role of PPARs in inflammation and immunity. J. Leukocyte Biology. 71:388-400, 2002.
Clark RB, Bishop-Bailey D, Estrada-Hernandez T, Hla T, Puddington L, Padula SJ: The nuclear receptor PPARg and immunoregulation. PPARg mediates inhibition of helper T cell responses. J. Immunol. 164:1364-1371, 2000.
Clark RB, Grunnet M, Lingenheld E: The generation of encephalitogenic T cell lines from EAE-resistant strains of mice. International Immunol. 9:1415-1422, 1997.
Barbarese E, Soares H, Yang S, Clark RB: Comparison of CNS homing pattern among murine TH cell lines responsive to myelin basic protein. J. Neuroimmunol. 39:151-162, 1992.
Padula SJ, Lingenheld EG, Stabach PR, Chou CHJ, Kono DH, Clark RB: Identification of encephalitogenic Vb-4-bearing T cells in SJL mice. Further evidence for the V-region disease hypothesis. J. Immunol. 146(3):879-883, 1991.
Ruddle NH, Bergman CM, McGrath MK, Lingenheld EG, Grunnet ML, Padula SJ, Clark RB: An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 11972:1193-1200, 1990.
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