My laboratory studies the cellular and molecular mechanisms of brain injury in inflammatory and inflammation-associated disorders of the central nervous system. For this purpose, we focus on (1) vascular triggers leading to the invasion of pathogenic lymphocytes into the normal and inflamed brain, (2) regulation of inflammatory and anti-inflammatory processes at the level of cell surface molecules, and (3) cellular mechanisms regulating injury or survival/regeneration of neurons in areas affected by inflammation.
Lab Rotation Projects:
Expression and function of lymphocyte recruitment signals at the blood-CNS barrier.
Selected Publications:
Franitza S, Grabovsky V, Wald O, Weiss I, Beider K, Dagan M, Darash-Yahana M, Nagler A, Brocke S, Galun E, Alon R, Peled A. 2004. Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells. Eur J Immunol. May;34(5):1333-41.
Beider K, Nagler A, Wald O, Franitza S, Dagan-Berger M, Wald H, Giladi H, Brocke S, Hanna J, Mandelboim O, Darash-Yahana M, Galun E, Peled A. 2003. Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T-cells to the bone marrow and spleen of NOD/SCID mice. Blood. Sep 15;102(6):1951-8.
Aktas O, Waiczies S, Smorodchenko A, Dorr J, Seeger B, Prozorovski T, Sallach S, Endres M, Brocke S, Nitsch R, Zipp F. 2003. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. J Exp Med. Mar 17;197(6):725-33.
Reinhold D, Kahne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S, Brocke S. 2002. The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. Biol Chem. Jul-Aug;383(7-8):1133-8. Review.
Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S. 2001. Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo. J Immunol. Feb 1;166(3):2041-8.
Brocke S. 2000. T cell receptor peptides for the vaccination therapy of multiple sclerosis. Ernst Schering Res Found Workshop; (30):167-79. Review.
Reinhold D, Hemmer B, Gran B, Steinbrecher A, Brocke S, Kahne T, Wrenger S, Born I, Faust J, Neubert K, Martin R, Ansorge S. 2000. Dipeptidyl peptidase IV (CD26): role in T cell activation and autoimmune disease. Adv Exp Med Biol.;477:155-60.
Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S. 2000. Dipeptidyl peptidase IV in inflammatory CNS disease. Adv Exp Med Biol.;477:145-53.
